New bioinformation tool to improve the precision of personalized nutrition, find researchers


Following a research initiative, a team of experts at the Genomics and Health Department, Foundation for the Promotion of Health and Biomedical Research have published an article in Nature Communications that demonstrates the bioinformation tool AGREDA.

The tool is a system for developing personalized nutrition plans that accounts for the biological composition of the microbiota of each individual.

Physiologically, over 100 billion microorganisms thrive in the human intestine and make up for the composition of intestinal microbiota. This impacts the development of several diseases that are related to the lifestyle of industrialized nations such as the one related to the immune system.

Furthermore, intestinal microbiota reacts to an individual’s diet and the processes many of the nutrients that are consumed with food.

The study is formulated within the European Stance4Health program, and the objective is to understand the transpiration process of nutrients by the intestinal microbiota, and the compounds that are produced to have an impact on the health in a positive manner or a negative manner.

Importantly, the new tool allows designing personalized diets that take into account an individual’s microbiota and clinical condition. This is to monitor the composition and working of microbiota that is optimal for each individual.

In fact, the sum of bioinformation techniques completes the metabolism of 250 nutrients, for example phenolic compounds. These compounds are present in plant foods such fruits, legumes, vegetables, and beverages such as tea and coffee.

Meanwhile, personalized nutrition tools currently used fundamentally uses the patient’s genetic data. This makes the approach to be incomplete and not optimal as it does lacks metabolic contribution of the intestinal microbiota, explains the lead author of the study.

The account of intestinal microbiota for personalized nutrition program has enormous potential, added the lead researcher.

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